Primary Literature, from most recent

  1. Kazakov T., F. Yang, H.N. Ramanathan, A. Kohlway, M.S. Diamond, B.D. Lindenbach. “Hepatitis C virus RNA replication depends on specific cis- and trans-acting activities of viral nonstructural proteins.” PLoS Pathogens. 2015, 11(4):e1004817 PubMed Link | Full Text Online
  2. Isken, O., U. Langerwisch, V. Jirasko, D. Rehders, L. Redecke, H. Ramanathan, B.D. Lindenbach, R. Bartenschlager, N. Tautz. “A conserved NS3 surface patch orchestrates NS2 protease stimulation, NS5A hyperphosphorylation and HCV genome replication.” PLoS Pathog. 2015, 11(3):e1004736 PubMed Link | Full Text Online
  3. Kohlway A., N. Pirakitikulr, S.C. Ding, F. Yang, D. Luo, B.D. Lindenbach, Pyle AM. “The linker region of NS3 plays a critical role in the replication and infectivity of hepatitis C virus.” J Virol. 2014, 88(18):10970-4. PubMed Link | Full Text Online
  4. Cordek D.G., T.J. Croom-Perez, J. Hwang, M.R. Hargittai, C.V. Subba-Reddy, Q. Han, M.F> Lodeiro, G. Ning G, T.S. McCrory, J.J. Arnold, H. Koc, B.D. Lindenbach, S.A. Showalter, C.E. Cameron. “Expanding the proteome of an RNA virus by phosphorylation of an intrinsically disordered viral protein.” J Biol Chem. 2014, 289(35):24397-416. PubMed Link | Full Text Online
  5. Hao L., B. Lindenbach, X. Wang, D. Dye, D. Kushner, Q. He Q, M. Newton, P. Ahlquist. “Genome-wide analysis of host factors in nodavirus RNA replication.” PLoS One. 2014, 9(4):e95799. PubMed Link | Full Text Online
  6. Paintsil E., M. Binka, A. Patel, B.D. Lindenbach, R. Heimer. “Hepatitis C Virus Maintains Infectivity for Weeks After Drying on Inanimate Surfaces at Room Temperature: Implications for Risks of Transmission.” J Infect Dis. 2014, 209(8):1205-11. PubMed Link | Full Text Online
  7. Kohlway A., N. Pirakitikulr, F.N. Barrera, O. Potapova, D.M. Engelman, A.M. Pyle, B.D. Lindenbach. “Hepatitis C virus RNA replication and virus particle assembly require specific dimerization of the NS4A protein transmembrane domain.” J Virol. 2014, 88(1):628-42. PubMed Link | Full Text Online
  8. Luo, D., S.C. Ding, A. Vela, A.S. Kohlway; B.D. Lindenbach, A.M. Pyle. “Structural insights into RNA recognition by RIG-I.” Cell. 2011, 147(2):409-422. PubMed Link | Full Text Online
  9. Counihan, N.A., S.M. Rawlinson, B.D. Lindenbach. “Trafficking of Hepatitis C Virus Core Protein During Virus Particle Assembly.” PLoS Pathogens, 2011, 7(10): e1002302. PubMed Link | Full Text Online
  10. Stapleford K., B.D. Lindenbach. “Hepatitis C virus NS2 coordinates virus particle assembly through physical interactions with the E1-E2 glycoprotein and NS3-NS4A enzyme complexes.” J Virol. 2011, 85(4):1706-17. PubMed Link | Full Text Online
  11. Phan T., A. Kohlway, P. Dimberu, A.M. Pyle, B.D. Lindenbach.  “The acidic domain of hepatitis C virus NS4A contributes to RNA replication and virus particle assembly.” J. Virol. 2011, 85(3):1193-204. PubMed Link | Full Text Online
  12. Paintsil E., H. He, C. Peters, B.D. Lindenbach, R. Heimer.  “Survival of hepatitis C virus in syringes: implication for transmission among injection drug users.”  J Infect Dis.  2010, 202(7):984-990. PubMed Link | Full Text Online
  13. Harding M.J., C.M. Lepus, T.F. Gibson, B.R. Shepherd, S.A. Gerber, M. Graham, F.X. Paturzo, C. Rahner, J.A. Madri, A.L. Bothwell, B.D. Lindenbach, J.S. Pober. “An implantable vascularized protein gel construct that supports human fetal hepatoblast survival and infection by hepatitis C virus in mice.” PLoS ONE. 2010, 5(4):e9987. PubMed Link | Full Text Online
  14. Cheng Y., L.K. Tsou, J. Cai, T. Aya, G.E. Dutschman, E.A. Gullen, S.P. Grill, A.P. Chen, B.D. Lindenbach, A.D. Hamilton, Y.C. Cheng. “A novel class of meso-tetrakis-porphyrin derivatives exhibits potent activities against hepatitis C virus genotype 1b replicons in vitro.” Antimicrob. Agents Chemother. 2010, 54(1):197-206. PubMed Link | Full Text Online
  15. Phan T., R.K. Beran, C. Peters, I.C. Lorenz, B.D. Lindenbach.  “Hepatitis C virus NS2 protein contributes to virus particle assembly via opposing epistatic interactions with the E1-E2 glycoprotein and NS3-NS4A enzyme complexes.” J. Virology 2009, 83(17):8379-8395. PubMed Link | Full Text Online
  16. Beran, R.K.F., B.D. Lindenbach, A.M. Pyle.  “The NS4A protein of hepatitis C virus promotes RNA-coupled ATP hydrolysis by the NS3 helicase.” J. Virol. 2009, 83(7):3268-3275. PubMed Link | Full Text Online
  17. Randall G., M. Panis, J.D. Cooper, T.L. Tellinghuisen, K.E. Sukhodolets, S. Pfeffer, M. Landthaler, P. Landgraf, S. Kan, B.D. Lindenbach, M. Chien, D.B. Weir, J.J. Russo, J. Ju, M.J. Brownstein, R. Sheridan, C. Sander, M. Zavolan, T. Tuschl, C.M. Rice. “Cellular cofactors affecting hepatitis C virus infection and replication.” Proc Natl Acad Sci U S A. 2007, 104(31):12884-9. PubMed Link | Full Text Online
  18. Tscherne D.M., M.J. Evans, T. von Hahn, C.T. Jones, Z. Stamataki, J.A. McKeating, B.D. Lindenbach, C.M. Rice. “Superinfection exclusion in cells infected with hepatitis C virus.” J Virol. 2007, 81(8):3693-703. PubMed Link | Full Text Online
  19. Lindenbach, B.D., B.M. Prágai, R. Montserret, R.K.F. Beran, A.M. Pyle, F. Penin, and C.M. Rice. “The C-terminus of hepatitis C virus NS4A encodes an electrostatic switch that regulates NS5A hyperphosphorylation and viral replication.” J. Virol. 2007, 81(17):8905-8918. PubMed Link | Full Text Online
  20. Randall G., L. Chen, M. Panis, A.K. Fischer, B.D. Lindenbach, J. Sun, J. Heathcote, C.M. Rice, A.M. Edwards, I.D. McGilvray. “Silencing of USP18 potentiates the antiviral activity of interferon against hepatitis C virus infection.” Gastroenterology. 2006, 131(5):1584-91. PubMed Link | Full Text Online
  21. von Hahn T., B.D. Lindenbach, A. Boullier, O. Quehenberger, M. Paulson, C.M. Rice, J.A. McKeating. “Oxidized low-density lipoprotein inhibits hepatitis C virus cell entry in human hepatoma cells.” Hepatology. 2006, 43(5):932-42. PubMed Link | Full Text Online
  22. Lindenbach, B.D.*, P. Meuleman*, A. Ploss, T. Vanwolleghem, A.J. Syder, J.A. McKeating, R.E. Lanford, S.M. Feinstone, M.E. Major, G. Leroux-Roels,  C.M. Rice. “Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro.” Proc. Natl. Acad. Sci. U.S.A. 2006, 103(10): 3805-3809. PubMed Link | Full Text Online
  23. Tscherne D.M., C.T. Jones, M.J. Evans, B.D. Lindenbach, J.A. McKeating, C.M. Rice. Time- and temperature-dependent activation of hepatitis C virus for low-pH-triggered entry.” J. Virol. 2006, 80(4):1734-41. PubMed Link | Full Text Online
  24. Lindenbach, B.D., M.J. Evans, A.J. Syder, B. Wölk, T.L. Tellinghuisen, C.C. Liu, T. Maruyama, R.O. Hynes, D.R. Burton, J.A. McKeating, C.M. Rice. “Complete replication of hepatitis C virus in cell culture.” Science 2005, 309:623-626. PubMed Link | Full Text Online
  25. Pfeffer S., A. Sewer, M. Lagos-Quintana, R. Sheridan, C. Sander, F.A. Grässer, L.F. van Dyk, C.K. Ho, S. Shuman, M. Chien, J.J. Russo, J. Ju, G. Randall, B.D. Lindenbach, C.M. Rice, V. Simon, D.D. Ho, M. Zavolan, T. Tuschl. “Identification of microRNAs of the herpesvirus family.” Nat Methods. 2005, 2(4):269-76. PubMed Link | Full Text Online
  26. Moradpour D., M.J. Evans, R. Gosert, Z. Yuan, H.E. Blum, S.P. Goff, B.D. Lindenbach, C.M. Rice. “Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes.” J. Virol. 2004, 78(14):7400-9. PubMed Link | Full Text Online
  27. Kushner D.B., B.D. Lindenbach, V.Z. Grdzelishvili, A.O. Noueiry, S.M. Paul, P. Ahlquist. “Systematic, genome-wide identification of host genes affecting replication of a positive-strand RNA virus.” Proc Natl Acad Sci U S A. 2003, 100(26):15764-9. PubMed Link | Full Text Online
  28. Bredenbeek P.J., E.A. Kooi, B. Lindenbach, N. Huijkman, C.M. Rice, W.J. Spaan. “A stable full-length yellow fever virus cDNA clone and the role of conserved RNA elements in flavivirus replication.” J Gen Virol. 2003, 84(5):1261-8. PubMed Link | Full Text Online
  29. Lindenbach B.D., S.Y. Sgro, P. Ahlquist. “Long-distance base pairing in Flock House virus RNA1 regulates subgenomic RNA3 synthesis and RNA2 replication.” J Virol. 2002, 76(8):3905-19. PubMed Link | Full Text Online
  30. Lindenbach B.D., C.M. Rice. “Genetic interaction of flavivirus nonstructural proteins NS1 and NS4A as a determinant of replicase function.” J Virol. 1999, 73(6):4611-21. PubMed Link | Full Text Online
  31. Lindenbach B.D., I. Frolov, C.M. Rice. “Construction of recombinant Sindbis-based expression vectors for the study of HCV genes and their products.” Methods Mol Med. 1999, 19:565-74. PubMed Link
  32. Agapov E.V., I. Frolov, B.D. Lindenbach, B.M. Prágai, S. Schlesinger, C.M. Rice. “Noncytopathic Sindbis virus RNA vectors for heterologous gene expression.” Proc Natl Acad Sci U S A. 1998, 95(22):12989-94. PubMed Link | Full Text Online
  33. Lindenbach B.D., C.M. Rice. “trans-Complementation of yellow fever virus NS1 reveals a role in early RNA replication.” J Virol. 1997, 71(12):9608-17. PubMed Link | Full Text Online
  34. Lin C., B.D. Lindenbach, B.M. Prágai, D.W. McCourt, C.M. Rice. “Processing in the hepatitis C virus E2-NS2 region: identification of p7 and two distinct E2-specific products with different C termini.” J Virol. 1994, 68(8):5063-73. PubMed Link | Full Text Online
  35. Kuhner C.H., B.D. Lindenbach, R.S. Wolfe. “Component A2 of methylcoenzyme M reductase system from Methanobacterium thermoautotrophicum ∆H: nucleotide sequence and functional expression by Escherichia coli.” J Bacteriol. 1993, 175(10):3195-203. PubMed Link | Full Text Online


Reviews and Book Chapters

  1. Lindenbach, B.D., C.M. Rice “The ins and outs of hepatitis C virus entry and assembly.” Nature Reviews of Microbiology. 2013, 11(10):688-700. PubMed Link | Full Text Online
  2. Lindenbach, B.D. “Virion assembly and release.” Curr Top Microbiol Immunol. 2013, 369:199-218. PubMed Link | Full Text Online
  3. Lindenbach, B.D., C.L. Murray, H.-J. Thiel, C.M. Rice. “Flaviviridae: The Viruses and Their Replication.”  Chapter 26 in D.M. Knipe, et al. (eds.), Fields Virology, 6th Edition.  Lippincott Williams & Wilkins, New York, NY. 2013
  4. Lindenbach, B.D. “Hepatitis C virus and hepatocellular carcinoma.” Chapter 23 in E.S. Robertson (ed.) Cancer Associated Viruses. Springer, Heidelberg, Germany. 2012. Full Text Online
  5. Lindenbach, B.D. “Understanding how hepatitis C virus builds its unctuous home.” Cell Host Microbe 2011, 9(1):1-2. PubMed Link | Full Text Online
  6. Lindenbach, B.D. “New cell culture models of hepatitis C virus entry, replication, and virus production.” Gastroenterology 2010, 139(4):1090-1093. PubMed Link | Full Text Online
  7. Lindenbach, B.D., Tellinghuisen, T. “Hepatitis C virus genome replication.” Chapter 6 in C.E. Cameron, et al. (eds.), Viral Genome Replication. Springer, Heidelberg, Germany. 2009. Full Text Online
  8. Lindenbach, B.D. “Measuring HCV infectivity produced in cell culture and in vivo.” Methods Mol. Biol. 2009, 510:329-336. PubMed Link | Full Text Online
  9. Lindenbach, B.D., Tellinghuisen, T. “Reverse Transcription PCR Based Sequence Analysis of HCV Replicon RNA.” Methods Mol. Biol. 2009, 510:165-175. PubMed Link | Full Text Online
  10. Counihan N.A., B.D. Lindenbach. “Gumming up the works: DNA polymers as HCV entry inhibitors.” Gastroenterology 2009 137(2):427-430. PubMed Link | Full Text Online
  11. Lindenbach, B.D., H.-J. Thiel, C.M. Rice. “Flaviviridae: The Viruses and Their Replication.” Chapter 33 in D.M. Knipe, et al. (eds.), Fields Virology, 5th edition. Lippincott Williams & Wilkins, New York, NY. 2006.
  12. Lindenbach, B.D., C.M. Rice. “Unravelling hepatitis C virus replication from genome to function.” Nature 2005, 436(7053): 933-938. PubMed Link | Full Text Online
  13. Lindenbach B.D., C.M. Rice. “Molecular biology of flaviviruses.” Adv Virus Res. 2003, 59:23-61. PubMed Link
  14. Lindenbach B.D., C.M. Rice. “Evasive maneuvers by hepatitis C virus.” Hepatology. 2003, 38(3):769-71. PubMed Link | Full Text Online
  15. Lindenbach B.D., C.M. Rice. “RNAi targeting an animal virus: news from the front.” Mol. Cell. 2002, 9(5):925-7. PubMed Link | Full Text Online
  16. Lindenbach, B.D., H.-J. C.M. Rice. “Flaviviridae: The Viruses and Their Replication.” Chapter 32 in D.M. Knipe, et al. (eds.), Fields Virology, 4th edition. Lippincott Williams & Wilkins, New York, NY. 2001.